Endocrine Abstracts

This study aims to evaluate patients who require PTH-treatment among the referral population with hypoparathyroidism.Methods: The information was collected from the registry database of chronic hypoparathyroidism, which was initiated by the National Medical Research Centre for Endocrinology (NMRCE).Results: Among 194 cases of hypoparathyroidism referred to our clinic over 2 years (2017–2019), eig...

Introduction: The aim of our study was to investigate clinical and morphological features of dopamine agonist-resistant prolactinomas.Methods/design: The study included 51 patients (38 women, 13 men) with prolactin-secreting pituitary adenoma that is resistant to treatment with dopamine agonists, age 15–82 years.Results: Median of the serum PRL level distribution at the onset of the disease was 4500 mIU/l (3480, 140 300). The ...

Prolactinomas are very rare, but usually more aggressive among children, than in adults. Although treatment strategies for prolactinomas in adults are well established and at present time the preference is given to dopamine agonists, the use of these drugs in pediatric patients is limited due to lack of information on safety and efficiency in this group of patients.A 14-year old boy presented with absent puberty, obesity (weight +4σ) general weaknes...

A role of autoimmune aggression is postulated in the pathogenesis of different diseases in endocrinology. Forty to sixty percent of cases of central diabetes insipidus (CDI) are considered to be idiopathic. Primary polydipsy is a diagnosis of an exclusion of diabetes insipidus on the basis of water deprivation test, but sometimes it precedes the overt CDI. Thus the aim of this study was to define the prevalence of pituitary autoantibodies in patients with CDI and primary polyd...

Background: MiRNAs are small non-coding RNAs, which regulate biological and pathological processes, including organogenesis, apoptosis, cell proliferation and differentiation. Considering the complexity of the parathyroid cancer (PC) diagnosis, discovering of new markers of the disease, which may help to evaluate the prognosis before surgical treatment, becomes an important problem. We studied the differences in miRNA expression profile in the blood serum between patients with...

Objective: To assess the levels of osmolality, sodium in blood and urine, and copeptin level in patients after transnasal adenomectomy for pituitary adenomas.Materials and methods: A total of 154 patients, aged 18 to 65 years, were included in this study and underwent transnasal adenomectomy. Surgical treatment was performed in 73 patients with Cushing’s disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inact...

Growth hormone (GH) producing tumors are commonly associated with menstrual disorders and anovulation because of the direct effects of tumor mass on gonadotropins and possible association with hyperprolactinemia. However, some women with acromegaly get pregnant, which rises up a lot of questions about medication, complications and follow-up. We report outcomes of 7 cases of pregnancy in patients with active acromegaly. A median age of patients was 30 years, four of them were w...

Aim: To assess the data of the registry concerning women with acromegaly.Materials and methods: Russian hypothalamic and pituitary tumors registry database, containing the information on 3968 acromegalic patients.Results: From all patients with acromegaly registered in the database, 2878 patients (72.5%) are women. We assessed the following data on gonadal status and reproductive function in this group: 512 patients have irregular ...

Introduction: Epidemiological data for central diabetes insipidus (CDI) are quite sparse.Objectives: To provide an epidemiological data on CDI in different regions of Russia (20 from 83 Federal regions).Materials and methods: We used the Russian Registry for Central Diabetes Insipidus (RCDI) to study the epidemiological features of CDI.Results: A total of 2004 patients with CDI were recorded, 47% women and 59...

Case description: A 26-year-old female visited an endocrinologist for the first time in 2014 with complaint of neck swelling. Lab results revealed increased blood level of TSH, initially the diagnosis of hypothyroidism was set and levothyroxine therapy was initiated with consequent addition of thiamazole due to increasing levels of free T4 and TSH. In 2015 the diagnosis of TSH-secreting adenoma was made on the basis of MRI findings (pituitary microadenoma 3.1 mm in size) and l...